We support our Publishers and Content Creators. You can view this story on their website by CLICKING HERE.

Published|Updated

You know the season is winding down once the NFL starts scheduling Saturday games. There is a purpose for these teams playing Saturday as all four play on Christmas too. Buckle up because there is NFL action to bet on Thursday, Saturday, Sunday, next Monday, and next Wednesday. Keep reading for the opening moneylines, spreads, and totals for Week 16 following Sunday Night Football in Week 15. 

NFL Week 16 Opening Lines 

The odds are courtesy of DraftKings as of 12:15 a.m. ET Monday, December 16. 

Thursday Night Football 

Denver Broncos (9-5) at Los Angeles Chargers (8-6) 

  • Moneyline (ML): Denver (+136) | LAC (-162)
  • Spread: Broncos +3 (-105) | Chargers -3 (-115)
  • Total — 43 — Over (-110) | Under (-110)

NFL Saturday (two games)

Houston Texans (9-5) at Kansas City Chiefs (13-1) 

  • ML: Houston (-130) | Kansas City (+110)
  • Spread: Texans -2 (-110) | Chiefs +2 (-110)
  • Total — 41.5 — Over (-110) | Under (-110)

Pittsburgh Steelers (10-4) at Baltimore Ravens (9-5) 

  • ML: Pittsburgh (+220) | Baltimore (-270)
  • Spread: Steelers +6 (-110) | Ravens -6 (-110)
  • Total — 46.5 — Over (-110) | Under (-110)

1 p.m. ET window, Sunday (seven games) 

New York Giants (2-12) at Atlanta Falcons (6-7)*

  • ML: NYG (+370) | Atlanta (-485)
  • Spread: Giants +9.5 (-110) | Falcons -9.5 (-110)
  • Total — 42.5 — Over (-110) | Under (-110)

Atlanta still needs to play the Las Vegas Raiders on Monday Night Football in NFL Week 15. 

New England Patriots (3-11) at Buffalo Bills (11-3) 

  • ML: New England (+625) | Buffalo (-950)
  • Spread: Patriots +14 (-110) | Bills -14 (-110)
  • Total — 46.5 — Over (-110) | Under (-110)

Buffalo Bills QB Josh Allen goes airborne for a first-down run vs. the Detroit Lions in NFL Week 15 at Ford Field. (Lon Horwedel-Imagn Images)

Buffalo Bills QB Josh Allen goes airborne for a first-down run vs. the Detroit Lions in NFL Week 15 at Ford Field. (Lon Horwedel-Imagn Images)

Detroit Lions (12-2) at Chicago Bears (4-9)**

  • ML: Detroit (-360) | Chicago (+285)
  • Spread: Lions -7.5 (-110) | Bears +7.5 (-110)
  • Total — 46.5 — Over (-110) | Under (-110)

**The Bears still have to play the Minnesota Vikings on Monday Night Football in NFL Week 15. 

Cleveland Browns (3-11) at Cincinnati Bengals (6-8) 

  • ML: Cleveland (+285) | Cincinnati (-360)
  • Spread: Browns +7 (-110) | Bengals -7 (-110)
  • Total — 49.5 — Over (-110) | Under (-110)

Tennessee Titans (3-11) at Indianapolis Colts (6-8) 

  • ML: Tennessee (+164) | Indianapolis (-198)
  • Spread: Titans +4 (-110) | Colts -4 (-110)
  • Total — 42 — Over (-110) | Under (-110)

Los Angeles Rams (8-6) at New York Jets (4-10) 

  • ML: LAR (-162) | NYJ (+162)
  • Spread: Rams –3 (-110) | Jets +3 (-110)
  • Total — 47.5 — Over (-110) | Under (-110)

Philadelphia Eagles QB Jalen Hurts scrambles away from the Pittsburgh Steelers at Lincoln Financial Field. (Bill Streicher-Imagn Images)

Philadelphia Eagles QB Jalen Hurts scrambles away from the Pittsburgh Steelers at Lincoln Financial Field. (Bill Streicher-Imagn Images)

Philadelphia Eagles (12-2) at Washington Commanders (9-5) 

  • ML: Philadelphia (-180) | Washington (+150)
  • Spread: Eagles -3.5 (-105) | Commanders +3.5 (-115)
  • Total — 46.5 — Over (-110) | Under (-110)

Arizona Cardinals (7-7) at Carolina Panthers (3-11) 

  • ML: Arizona (-218) | Carolina (+180)
  • Spread: Cardinals -4.5 (-110) | Panthers +4.5 (-110)
  • Total — 46.5 — Over (-110) | Under (-110)

4 p.m. ET window, Sunday (three games) 

Minnesota Vikings (11-2)*** at Seattle Seahawks (8-6) 

  • ML: Minnesota (-230) | Seattle (+190)
  • Spread: Vikings -4.5 (-110) | Seahawks +4.5 (-110)
  • Total — 41.5 — Over (-110) | Under (-110)

Jacksonville Jaguars (3-11) at Las Vegas Raiders (2-11)**** 

  • ML: Jacksonville (-105) | Las Vegas (-115)
  • Spread: Jaguars +1 (-110) | Raiders -1 (-110)
  • Total — 39.5 — Over (-110) | Under (-110)

The Raiders still need to play on Monday Night Football in NFL Week 12 vs. the Falcons. 

San Francisco 49ers (6-8) at Miami Dolphins (6-8) 

  • ML: San Francisco (+110) | Miami (-130)
  • Spread: 49ers +2 (-110) | Dolphins -2 (-110)
  • Total — 46.5 — Over (-110) | Under (-110)

Sunday Night Football 

Tampa Bay Buccaneers (8-6) at Dallas Cowboys (6-8) 

  • ML: Tampa Bay (-225) | Dallas (+185)
  • Spread: Buccaneers -4.5 (-110) | Cowboys +4.5 (-110)
  • Total — 48.5 — Over (-110) | Under (-110)

Tampa Bay Buccaneers QB Baker Mayfield throws the ball vs. the Los Angeles Chargers in NFL Week 15 at SoFi Stadium. (Gary A. Vasquez-Imagn Images)

Tampa Bay Buccaneers QB Baker Mayfield throws the ball vs. the Los Angeles Chargers in NFL Week 15 at SoFi Stadium. (Gary A. Vasquez-Imagn Images)

Monday Night Football

New Orleans Saints (5-9) at Green Bay Packers (10-4) 

  • Houston: New Orleans (+550) | Green Bay (-800)
  • Spread: Saints +13 (-110) | Packers -13 (-110)
  • Total — 42.5 — Over (-110) | Under (-110)

_____________________________

Follow me on X (or Twitter, whatever) @Geoffery-Clark, and check out my OutKick Bets Podcast for more betting content and random rants. I’ll add bets to my NFL 2024-25 betting record via X all season.