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More than 107,000 Americans died from drug overdoses last year, according to government findings released yesterday. The preliminary tally is the highest on record and 15% higher than the previous year. 

Overdose deaths have more than doubled since 2015, fueled by the increasing prevalence of fentanyl, a synthetic opioid roughly 50 times more potent than heroin (how it works, w/video). Fentanyl was responsible for two-thirds of total deaths, while heroin accounted for less than 10%—a figure that has steadily dropped as the use of illicit synthetic opioids has risen. Deaths involving stimulants such as meth rose by 34% to around 33,000.

Only three states reported year-over-year decreases—New Hampshire, Maryland, and Hawaii. See data here.